Dr. Catherine C.L. Wong is the Director of Center for Precision Medicine Multi-omics Research (CPMMR), Associate Professor with Tenure at School of Basic Medical Sciences, Peking University Health Science Center, Principal Investigator at Peking University-Tsinghua University Center for Life Sciences (CLS), and Honorary Professor at the University of Manchester. She is also awarded the Chinese Academy of Sciences Introduces Outstanding Technical Talents (Technology Hundred Persons Plan).
Dr. Wong has been dedicating to the development of cutting-edge mass spectrometry technologies and the applications in basic biology and clinical research. For instance, she developed the absolute quantitation method (TIMLAQ-MS) has been recently published in the journal Cell. Currently, the number of protein identification from one single somatic cell, using gOAD Chip single-cell proteomics technique developed by her team in 2018 (Anal Chem), is in the leading position in the world. Her mass spectrometry expertise has greatly assisted the Academician of the Chinese Academy of Sciences, President of West Lake University, Professor Yigong Shi, to discover the structure of Spliceosome in 3-angstrom resolution of CryoEM (Science, 2015 & 2016). In addition, Dr. Wong has long been committing to discovering true biomarkers and unveiling disease mechanisms. Starting from clinical problems, aiming at diagnostic markers and drug targets, she establishes large clinical cohorts accordingly, uses integrated-omics technologies with artificial intelligence data analysis. The authentic biomarkers could be screened out for further functional and expanded sample size validation. The ongoing collaborative projects cover more than 10 diseases, such as HBV liver disease, Stroke, Neuro degenerative diseases and others. Up to now, she has published more than 80 SCI papers, including Cell, Nature, Science and PNAS, etc.
1. Multiple signaling roles of CD3ε and its application in CAR-T cell therapy. Cell. 2020,
Published Online (https://doi.org/10.1016/j.cell.2020.07.018).
2. Parallel Channels-Multidimensional Protein Identification Technology (PC-MudPIT). Journal
of the American Society for Mass Spectrometry. 2020, 31(7), 1440-1447.
3. Nanoliter-Scale Oil-Air-Droplet Chip-Based Single Cell Proteomic Analysis. Anal Chem, 2018,
4. Therapeutic Mechanism Studies of ShuFengJieDu Capsule on an Acute Lung Injury Animal
Model Using Quantitative Proteomics Technology, Journal of proteome research, 2017,
5. pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and
one-step mass spectrometry for intact glycopeptide identification, Nature Communications, 2017.
Keynote Lecture: Proteomics approach for developing new CAR-T therapeutic methods