Norm Dovichi has played a pioneering role in a range of analytical research topics. In the 1980s, he introduced the concept of single-molecule detection to the chemical literature; in recognition of this work, he was invited as a plenary lecturer at the Nobel Conference on Single Molecule Spectroscopy held in 1999. In the 1990s, his group developed capillary array electrophoresis instruments for high-throughput DNA sequencing. He was recognized for this work by the journal Science as an “Unsung Hero of the Human Genome Project” and he was a plenary lecturer at the symposium on the Evolution of DNA Sequencing Technology, held at Cold Springs Harbor in 2015. Over the last decade, his group has focused its attention on coupling capillary electrophoresis with tandem mass spectrometry as a tool for high throughput and high sensitivity proteomic analysis. This instrumentation has been patented and is now marked by CMP Scientific and Agilent. Finally, his group has recently coupled capillary electrophoresis with next-generation DNA sequencing for the comprehensive metagenomic analysis of complex environmental microbiomes.
Plenary Lecture: Capillary electrophoresis and the sequencing of the human genome